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There are many methods in the scientific literature to prepare phenylacetone, and due to its status as a controlled substance, there is crossover into popular literature such as works by [[Uncle Fester (author)|Uncle Fester]] and [[Alexander Shulgin]]. Large amounts of data are available on the Internet relating to the preparation of phenylacetone.
There are many methods in the scientific literature to prepare phenylacetone, and due to its status as a controlled substance, there is crossover into popular literature such as works by [[Uncle Fester (author)|Uncle Fester]] and [[Alexander Shulgin]]. Large amounts of data are available on the Internet relating to the preparation of phenylacetone.


A conceptually simple example of phenylacetone [[organic synthesis]] is the [[Friedel-Crafts reaction|Friedel-Crafts alkylation]] of [[benzene]] with [[chloroacetone]].
A conceptually simple example of phenylacetone [[organic synthesis]] is the [[Friedel-Crafts reaction|Friedel-Crafts acylation]] of [[benzene]] with [[chloroacetone]].


:[[File:P2p-chloroacetone.gif|Phenylacetone synthesis via the Friedel-Crafts acylation of benzene with chloroacetone.]]
:[[File:P2p-chloroacetone.gif|Phenylacetone synthesis via the Friedel-Crafts acylation of benzene with chloroacetone.]]

Revision as of 14:33, 12 April 2012

Phenylacetone
Skeletal formula
Skeletal formula
Ball-and-stick model
Ball-and-stick model
Names
IUPAC name
1-phenylpropan-2-one
Other names
benzyl methyl ketone; methyl benzyl ketone; phenyl-2-propanone
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.002.859 Edit this at Wikidata
KEGG
UNII
  • InChI=1S/C9H10O/c1-8(10)7-9-5-3-2-4-6-9/h2-6H,7H2,1H3 checkY
    Key: QCCDLTOVEPVEJK-UHFFFAOYSA-N checkY
  • InChI=1/C9H10O/c1-8(10)7-9-5-3-2-4-6-9/h2-6H,7H2,1H3
    Key: QCCDLTOVEPVEJK-UHFFFAOYAG
  • O=C(C)Cc1ccccc1
Properties
C9H10O
Molar mass 134.178 g·mol−1
Density 1.006 g/mL
Melting point −15 °C (5 °F; 258 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)

Phenylacetone (known also as phenyl-2-propanone, benzyl methyl ketone, or methyl benzyl ketone), is an organic compound. It is a clear oil with a refractive index of 1.5168. This substance is used in the manufacture of methamphetamine and amphetamine as a starting material or intermediate, where it is commonly known as P2P. Due to the illicit uses in clandestine chemistry, it was declared a schedule II controlled substance in the United States 11. February 1980.[1]

Preparation

There are many methods in the scientific literature to prepare phenylacetone, and due to its status as a controlled substance, there is crossover into popular literature such as works by Uncle Fester and Alexander Shulgin. Large amounts of data are available on the Internet relating to the preparation of phenylacetone.

A conceptually simple example of phenylacetone organic synthesis is the Friedel-Crafts acylation of benzene with chloroacetone.

Phenylacetone synthesis via the Friedel-Crafts acylation of benzene with chloroacetone.

Phenylacetone can also be produced from many other compounds. For example:

Phenyl acetone is used as an intermediate to produce pesticides and anticoagulants. Active ingredients as anticoagulants include:

See also

  • MDP2P - related compound with a methylenedioxy group, and a precursor to MDMA.

References