Phenylacetone: Difference between revisions
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There are many methods in the scientific literature to prepare phenylacetone, and due to its status as a controlled substance, there is crossover into popular literature such as works by [[Uncle Fester (author)|Uncle Fester]] and [[Alexander Shulgin]]. Large amounts of data are available on the Internet relating to the preparation of phenylacetone. |
There are many methods in the scientific literature to prepare phenylacetone, and due to its status as a controlled substance, there is crossover into popular literature such as works by [[Uncle Fester (author)|Uncle Fester]] and [[Alexander Shulgin]]. Large amounts of data are available on the Internet relating to the preparation of phenylacetone. |
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A conceptually simple example of phenylacetone [[organic synthesis]] is the [[Friedel-Crafts reaction|Friedel-Crafts |
A conceptually simple example of phenylacetone [[organic synthesis]] is the [[Friedel-Crafts reaction|Friedel-Crafts acylation]] of [[benzene]] with [[chloroacetone]]. |
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:[[File:P2p-chloroacetone.gif|Phenylacetone synthesis via the Friedel-Crafts acylation of benzene with chloroacetone.]] |
:[[File:P2p-chloroacetone.gif|Phenylacetone synthesis via the Friedel-Crafts acylation of benzene with chloroacetone.]] |
Revision as of 14:33, 12 April 2012
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Names | |
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IUPAC name
1-phenylpropan-2-one
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Other names
benzyl methyl ketone; methyl benzyl ketone; phenyl-2-propanone
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Identifiers | |
3D model (JSmol)
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ChEBI | |
ChemSpider | |
ECHA InfoCard | 100.002.859 |
KEGG | |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C9H10O | |
Molar mass | 134.178 g·mol−1 |
Density | 1.006 g/mL |
Melting point | −15 °C (5 °F; 258 K) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Phenylacetone (known also as phenyl-2-propanone, benzyl methyl ketone, or methyl benzyl ketone), is an organic compound. It is a clear oil with a refractive index of 1.5168. This substance is used in the manufacture of methamphetamine and amphetamine as a starting material or intermediate, where it is commonly known as P2P. Due to the illicit uses in clandestine chemistry, it was declared a schedule II controlled substance in the United States 11. February 1980.[1]
Preparation
There are many methods in the scientific literature to prepare phenylacetone, and due to its status as a controlled substance, there is crossover into popular literature such as works by Uncle Fester and Alexander Shulgin. Large amounts of data are available on the Internet relating to the preparation of phenylacetone.
A conceptually simple example of phenylacetone organic synthesis is the Friedel-Crafts acylation of benzene with chloroacetone.
Phenylacetone can also be produced from many other compounds. For example:
- phenylacetic acid is distilled with lead acetate or calcium acetate to yield phenylacetone.
- benzaldehyde is reacted with nitroethane yielding phenyl-2-nitropropene, which is reduced, usually in the presence of acid, to phenylacetone.
Phenyl acetone is used as an intermediate to produce pesticides and anticoagulants. Active ingredients as anticoagulants include:
- Brodifacoum
- Chlorophacinone
- Coumachlor
- Difenacoum
- Diphenadione
- 2-Pivaloyl-1,3-indandione
- 2-Isovaleryl-1,3-indandione
- Warfarin